ROLE OF -2 FAMILY PROTEINS AT THE CROSSROADS OF CA 2+ SIGNALING AND CELL HOMEOSTASIS

Orateur : Pierre-Germain GILLET (CRCL, Lyon)

Local invasion can be considered as an initial and essential step in the malignancy of carcinomas, leading to the generation of distant metastasis. Metastasis remains the major cause of cancer-related mortality and currently, there is a lack of therapies that can efficiently prevent this process. The molecular mechanisms governing tumor progression, including metastasis development, are still poorly understood. During this process, cells acquire apoptosis resistance, which is often correlated with alteration of Bcl-2 family proteins status. Bcl-2 family members are the main regulators of apoptosis. Upregulation of the anti-apoptotic members in wide range of cancers including breast cancer is often correlated with chemotherapy resistance and poor prognosis. Thus targeting the activity of Bcl-2 family proteins represents promising strategies for the elaboration of cancer therapeutic. Bcl-2 proteins have been studied intensively for the past two decades owing to their importance in the regulation of apoptosis, tumorigenesis and cellular responses to anti-cancer therapy. However, increasing data suggest additional roles, including regulation of the cell cycle, metabolism and cytoskeletal dynamics. Based on our recent results using zebrafish as a model, we will discuss the contribution of this fascinating family of proteins to the control of cell death, proliferation and migration in the context of early development and cancer.

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