Neural circuits for the social learning influence on food preference
Jeudi 20 septembre 2018 11:30
- Duree : 1 heure
Lieu : Amphithéâtre Serge Kampf, Grenoble Institut des Neurosciences (GIN) - Bât. Edmond J. Safra, Chemin Fortune Ferrini CHU, La Tronche
Orateur : Michaël LOUREIRO (University of Western Ontario, London, Canada)
Using information acquired from peers is a powerful strategy for many species to decide which food to eat. Exposure to an odor during conspecific interactions can influence food choice, a phenomenon dubbed social transmission of food preference (STFP). This decision requires the transformation of olfactory perceptions into value-based actions. The former is known to involve the piriform cortex (PiC), while consumption is driven by the activity of neurons in the nucleus accumbens (NAc). In the present study we show that the mPFC is a necessary relay for STFP undergoing plasticity when exposed to a conspecific. Neuroanatomical tracing showed a prominent connection from PiC onto mPFC neurons that target the nucleus accumbens (NAc-projectors). Conspecific interaction increased the excitatory-to-inhibitory balance in NAc-projectors, which were markedly engaged during food choice. Inhibition of PiC to mPFC pathway prevented STFP ac-
Contact : sebastien.carnicella@univ-grenoble-alpes.fr ou frederic.saudou@univ-grenoble-alpes.fr
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