AMPKα2 AS A REGULATOR OF MUSCLE CELL DIFFERENTIATION AND SKELETAL MUSCLE HOMEOSTASIS

Orateur : Rémi MOUNIER (INMG, Lyon)

program to repair damaged myofibers. The molecular mechanisms controlling satellite cell fate only start to be understood. Moreover, regulation of stem cell fate, and especially the exit from and the entry into the quiescent state, depends on the metabolism of the cells. AMP kinase (AMPK).is an excellent candidate in the control of stem cell fate choice in adult muscle stem cells. Indeed, AMPK is a master regulator of energy and metabolism homeostasis of the cell. AMPK controls the polarity of some cell types and was shown to regulate cell cycle and cell growth by phosphorylation of a series of effectors controlling the cell cycle. We have demonstrated that an AMPKα1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis (Theret et al., 2017). AMPK alpha catalytic subunit exists under 2 isoforms exhibiting different substrate affinities and activating properties. We have shown that AMPKα2 is expressed during myogenesis only after the induction of muscle cell differentiation (Lantier et al., 2010). However, its functions in cell fate remain unknown. One aim of our group is to decipher the role of AMPKα2 in skeletal muscle homeostasis and to identify novel molecular targets of AMPKα2 that are involved in the regulation of muscle stem cell fate.

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