ATTENTION !!! SEMINAIRE ANNULE !!! Characterization of novel Brucella effector proteins

Orateur : Suzanna SALCEDO (Institut de Biologie et Chimie des Protéines, Lyon)

Brucellosis, caused by bacteria of the genus Brucella, is considered by World Health Organization to be the world’s most widespread bacterial zoonosis and a neglected zoonotic disease. Brucella are intracellular pathogens that replicate in an endoplasmic reticulum-derived compartment in a variety of cell types in both animals and humans. Brucella rely on a type IV secretion system VirB, that translocates effector proteins into host cells during infection and are capable of extensive modulation of host cellular responses. To date, only a few effector proteins have been characterized. We have recently identified two effectors, BnpA and BnpB, which target the host nucleus during infection and modulate sub-nuclear spatial dynamics. The characterization of these novel nucleomodulins will be presented, their host cellular targets and the molecular interactions taking place. We will also discuss their role in Brucella pathogenesis.

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