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Chemical Detoxification of Neurotoxic Methylmercury by Smart Molecules

Jeudi 29 novembre 2018 11:00 - Duree : 1 heure
Lieu : CEA, Bâtiment C5, Salle 421A - 17 rue des martyrs - 38000 Grenoble

Orateur : Gouriprasanna ROY (Department of Chemistry, Shiv Nadar University, Inde)

Abstract : Methylmercury (MeHg+) is considered to be the most toxic form of mercury due to its ability to accumulate in fat tissues leading to its bio-magnification within the food chain. The toxicological implications associated with the ingestion of MeHg+ may also differ according to its chemical form In nature, however, several microorganisms have been reported as being MeHg+ tolerant due to their ability to convert highly toxic MeHg+ to either less toxic volatile elemental mercury, Hg0 or biologically inert insoluble HgS (metacinnabar). For instance, bacterial organomercurial lyase (MerB) catalyzes the protolytic cleavage of the otherwise inert HgC bond of MeHg+ and produces methane (CH4) gas and ionic mercury Hg2+, while a second enzyme mercuric ion reductase (MerA) reduces the product Hg2+ to volatile Hg0. On the other hand, several sulfate reducing bacteria (SRB) convert highly toxic MeHg+ to less toxic insoluble HgS(s) by producing H2S during metabolism. In addition, insoluble mercury selenide (HgSe) particles have also been found in a wide range of tissues of marine mammals (whales and dolphins) and also detected in various organs (kidney, liver, muscle, and brain) of humans exposed to MeHg+. HgSe is considered to be much less toxic than mobile, soluble MeHg+ species including MeHgCys and MeHgSG. In this talk I will mostly focus on how small organic molecules can be used intelligently to detoxify highly neurotoxic methylmercury by two distinct pathways, similar to those observed in nature.

Contact : Pascale DELANGLE - 04.38.78.92.22

Discipline évènement : (Biologie / Chimie)
Entité organisatrice : (INAC/SyMMES)
Nature évènement : (Séminaire)
Site de l'évènement : Site CEA avec accès badge

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