Molecular Mechanisms of Prion and Amyloid Propagation Explored by Solid-State NMR Spectroscopy

Orateur : Christopher JARONIEC (Department of Chemistry & Biochemistry, The Ohio State University, Colombus, United States)

I will introduce the basics of structural and dynamic studies of biological macromolecules by magic-angle spinning solid-state nuclear magnetic resonance (NMR) spectroscopy, and discuss the application of this methodology toward providing an atomic level understanding of the phenomena of amyloid strains and cross-seeding barriers in a family of mammalian prion protein variants. If time permits, I will also discuss our recent advances in the development of new paramagnetic solid-state NMR methodologies for the rapid determination of three-dimensional protein structures.

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