SCALING IN MORPHOGENESIS : CONTROL OF CELL SHAPE CHANGES AND MECHANICAL TENSION DURING EPITHELIAL CONTRACTION

Orateur : Jérôme SOLON (CRG, Barcelona, Spain)

During embryogenesis, dramatic tissue reorganization occurs under the control of specific signaling pathways. Mechanical forces are coordinated in order to rearrange biological tissues and shape organs. The mechanisms at the origin of the generation and regulation of these forces during development to ensure correct cell positioning and tissue shaping remain elusive. Using Drosophila as a model, my group is interested in understanding the principles underlying the control of fundamental modes of tissue remodeling such as epithelial contraction, tissue spreading, folding and sealing during development. Here, I will present recent works on the generation and regulation of forces during tissue contraction and show an unusual contractile mechanism involving apoptosis in Drosophila dorsal closure. I will also discuss new results on the mechanisms controlling cell/cell junctional length and tension and ensuring scaling during epithelial contraction.

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