Current understanding on biophysical effect of Coulomb/Photoelectric nanoradiator effect
Mardi 5 février 2019 11:00
- Duree : 1 heure
Lieu : CEA, Bâtiment C5, Salle 421A - 17 rue des martyrs - 38000 Grenoble
Orateur : Jong-Ki KIM (Catholic University of Daegu, School of Medicine, Daegu 42472 S. Korea)
Nanoparticle-mediated therapeutic enhancement in radiotherapy involves secondary radiation emission from ion or X-ray photon impact on med-high Z nanoparticles. Low energy electron (LEEs) and characteristic X-ray fluorescence are typical secondary radiation emitted (NRD : nanoradiator) from the surface of nanoparticles under irradiation. In consideration of aqueous subcellular distribution of nanoparticles, enhanced production of ROS and various biological responses to oxidative stress are anticipated depending on the nanoparticle position and density. Measurement of ROS is a convenient way to quantify dose-enhancement or biological response as a chemical bridge between NRD and biology. Various ways are considered to understand the biophysical and therapeutic effect of Coulomb/Photoelectric nanoradiator phenomena by measuring directly the amounts of LEEs or XFL emission, indirectly ROS or DNA adduct by LEEs or cytokines release. In this regard, H2O2-based therapeutic enhancement is a new insight of NRD-mediated therapy. A number of possible way leading to dosimetry, theoretical formalism and proof-of-concept experiment are discussed in this talk.
Contact : Jean-Luc Ravanat - 04.38.78.47.97
Discipline évènement : (Biologie / Chimie)
Entité organisatrice : (INAC/SyMMES)
Nature évènement : (Séminaire)
Site de l'évènement : Site CEA avec accès badge
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