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Zebrafish through the looking glass : An in vivo glimpse at cardiovascular pathologies

Mardi 26 février 2013 11:00 - Duree : 1 heure
Lieu : Salle de Conférence de l’IAB - Rond Point de La Chantourne - La Tronche (arrêt de tram Grand Sablon, ligne B)

Orateur : Salim SEYFRIED (Max-Delbrück-Center for Molecular Medicine, Berlin)

Vertebrate organs are derived from epithelial or endothelial sheets of cells that undergo complex morphogenetic transformations. We study the early zebrafish heart, a relatively simple organ compared with its mammalian counterpart, to better understand the signaling events that instruct the assembly of the early heart tube and of its associated blood vessels. Initially this organ consists of only the outer myocardial and inner endocardial cell layers. An important part of our research is to elucidate the signals that regulate the morphogenesis of myocardium and endocardium and to understand to what extent these two tissues communicate during cardiac jogging and looping. A particular emphasis is on the mechanisms by which TGF-ß signaling (mainly Nodals and BMPs) control cardiac morphogenesis. Another research aim is to decipher the molecular signaling events that determine the differentiation of endocardium into its different morphological derivatives such as cushion cells. In this context, we are characterizing the role of the Cerebral Cavernous Malformations (CCM) proteins that have been implicated in endothelial vessel formation and maintenance of vascular integrity. In zebrafish and mouse, loss of CCM proteins causes massive cardiac ballooning, a failure of cardiac cushions to form, and a lack of cardiac looping. Using a highly-interdisciplinary approach, which includes detailed expression analyses combined with functional studies and high-resolution live imaging, we are trying to identify the underlying molecular mechanism(s) in this group of diseases.

Contact : Alicia.Lajmanovich@ujf-grenoble.fr

Discipline évènement : (Biologie / Chimie)
Entité organisatrice : (IAB)
Nature évènement : (Grand public) -
Nature évènement : (Séminaire)
Evènement répétitif : (Mardis de l’IAB)
Site de l'évènement : Pôle Santé / La Tronche

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