Mechanisms underlying neuronal selection and programmed cell death during adult neurogenesis in the olfactory bulb

Orateur : Jean-Claude PLATEL (IBDM, Université d'Aix-Marseille)

During development, the nervous system generates an excess of neurons. Around half of these neu-rons will be selected and establish neuronal network while the second half will be eliminated by programmed cell death (PCD). We are particularly interested by this selection step and we are trying to understand what are the parameters that will control the life or death decision. In this project we use neurogenesis in the olfactory bulb (OB) to study neuronal integration, selection and pro-grammed cell death directly in vivo. OB neurogenesis has been considered a competitive process in which new interneurons compete during their synaptic integration phase. Well-integrated and active neurons are thought to survive while non-competitive ones die by PCD. Despite a wealth of evi-dence supporting this model, systematic in vivo observations of the process are still scarce. We combine genetic and imaging approaches in the living animal that will allow us for the first time to manipulate and to observe in real time neuronal death in the brain of living rodents.

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