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Axon tension regulates fasciculation / defasciculation through the control of axon shaft zippering

Jeudi 12 septembre 2019 11:30 - Duree : 1 heure
Lieu : Amphithéâtre Serge Kampf, Grenoble Institut des Neurosciences (GIN) - Bât. Edmond J. Safra, Chemin Fortune Ferrini CHU, La Tronche

Orateur : Alain TREMBLEAU (Institut de Biologie Paris Seine)

The construction of axonal projections from a given neural tissue to its final target is in many cases a multistep process, in which individual axons are sequentially guided from one area to another by cues inducing specific decisions at the level of axonal growth cones. A fundamental principle go-verning axon pathfinding resides in the control of their fasciculation and defasciculation. Despite the key roles played by axon fasciculation and defasciculation in the development of the nervous system, little is known about their dynamics and the underlying biophysical mechanisms. In a model system composed of neurons grown ex vivo from explants of embryonic mouse olfactory epithelia, we observed that axons dynamically interact with each other through their shaft, leading to zip-pering and unzippering behavior that regulates their fasciculation. Using pharmacological and bio-physical manipulations, we showed that zippering arises from the competition between axon-axon adhesion and mechanical tension in the axons, hence uncovering an unexpected role of tension in the regulation of axon fasciculation. Furthermore, taking advantage of the relationship between axon tension and adhesion at zippers, we assessed an estimate of the axon:axon adhesion force by measuring axon tension using the Biomembrane Force Probe technique. In this talk, I will present these data obtained ex vivo, and our current strategy aiming at investigating the role of mechanical tension in the fasciculation and sorting of olfactory axons in vivo, in the live zebrafish.

Contact : Annie.Andrieux@univ-grenoble-alpes.fr

Discipline évènement : (Biologie / Chimie)
Entité organisatrice : (GIN)
Nature évènement : (Séminaire)
Evènement répétitif : (Séminaire Grenoblois de Neurosciences)
Site de l'évènement : Pôle Santé / La Tronche

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