Toward microscopic simulations of crowded cell-like environments

Orateur : Fabio STERPONE (Laboratoire de Biochimie Théorique, Institut de Biologie Physico-Chimique, Paris)

In this talk we present multi-scale simulations of bio-systems based on a novel computational framework. The developed methodology is used for exploring protein diffusion, stability and aggregation processes at mesoscale as in the intracellular environment. It can be deployed to explore the reshuffling of a protein crowded solution, to investigate the mechanism underlying protein mobility slowdown, and ultimately to extract the typical geometries of local packing around the proteins. It also allows by using different resolutions to explore multi-scale processes like the amyloid aggregation. In the talk we will cover several examples of our on going research, with a special focus on amyloid aggregation, and protein stability and diffusion in crowded solutions.

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