Engineering silicon surfaces ; chemo-topographic micro-contrasts with scaled cell adhesion response
Jeudi 28 mars 2013 09:30
- Duree : 1 jour 8 heures
Lieu : Salle de Conférence du LMGP, 2ème étage, Bât Phelma MINATEC - 3 parvis Louis Néel - Grenoble
Orateur : Dr. Miguel MANSO (Departamento de Fisica Aplicada
Universidad Autonoma de Madrid, Espagne)
The main topic of the presentation will be the description of the formation of Si versus Porous Silicon (PSi) contrasts, including processing, characterization and applications. Multiscale stripe micropatterns of Si and PSi have beenfabricated by means of a secuential high-energy ion-beam irradiation and electrochemical process. The surface properties of porous silicon areas evolve rapidly in phosphate-buffered saline. X-ray photoelectron spectra indicate the formation of a Si-OH and C-O enriched PSi surface, which becomes increasingly hydrophilic with aging time.
1D micropatterns have been used to analyze human mesenchymal stem cell (hMSC) adhesion. The actin cytoskeleton of hMSCs orients following the uniaxial micropatterns. In the wider Si stripes, hMSCs are dominantly located on Si areas. However, for reduced Si widths, adhesion is avoided on PSi by a split assembly of the actin cytoskeleton on two parallel Si areas. Further relevant observations stem from the formation of 2D micropatterns, which allow observing a MSCs anchoring following the squared lattice of the PSi/Si micropattern.
Contact : colette.lartigue@minatec.inpg.fr
Discipline évènement : (Physique)
Entité organisatrice : (LMGP)
Nature évènement : (Conférence de plusieurs jours)
Site de l'évènement : Site Minatec
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