THE ROLE OF CELLULAR FORCES IN ANGIOGENESIS

Orateur : Hans VAN OOSTERWYCK (KU Leuven , Belgium)

Cell-cell and cell-matrix mechanical interactions are indispensable for the formation of newblood vessels, given the fact that cell shape changes, migration, multicellular dynamics and organization requires the use of cellular forces. Over the past 5 years we have worked on in vitro models, experimental and computational tools to quantify the forces exerted by endothelial cells during migration and vascular invasion. In this seminar I will give an overview of the tools we have developed and highlight potential applications in vascular biology.

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