« mars 2024 »
L M M J V S D
26 27 28 29 1 2 3
4 5 6 7 8 9 10
11 12 13 14 15 16 17
18 19 20 21 22 23 24
25 26 27 28 29 30 31
 
Tous les évènements de Physique à venir

Tous les évènements de Biologie / Chimie à venir

Tous les évènements à venir

Les évènements relevant de la Physique et de la Biologie / Chimie sont représentés en turquoise

Interaction entre la machinerie de réplication des virus grippaux et le système d’import nucléaire cellulaire

Mardi 19 janvier 2021 13:30 - Duree : 2 heures
Lieu : VISIO-CONFERENCE

Orateur : Soutenance de Thèse de Amélie DONCHET (IRIG/IBS)

Merci de noter qu’en raison de la situation sanitaire, les soutenances de janvier seront retransmises par visioconférence.

Lien pour suivre par visioconférence : https://testbbbibs.isbg.fr/b/odi-lqv-hhf

In 2014, American and Chinese studies have identified the influenza D virus (IDV). This new member of the Orthomyxoviridae family shares only 50% sequence identity with the already well characterized influenza C virus and less than 30% sequence identity with influenza A and B viruses. IDV has been detected in pigs and cattle, and has been shown to replicate in the ferret, the main animal model for influenza virus studies in humans, suggesting a possible transmission. In 2018, a new study identified the first influenza viruses infecting cold-blooded animals. A phylogenetic comparison highlighted that these viruses, and more particularly a toad-infecting virus (ToadV), were closer to influenza B viruses than influenza A viruses. This relationship is surprising, taking into account the influenza B restricted host spectrum in comparison to the influenza A one. After the work on influenza A and B viruses and in line with it, the team collaborates now with Mariette Ducatez (INRA - ENV Toulouse) to detail the IDV replication, but also the replication machinery of ToadV. The replication machinery comprises various proteins, including the RNA polymerase (RdRp) and the nucleoprotein (NP). The RdRp is composed of three subunits (PA, PB1 and PB2), binds both the highly conserved 3’- and 5’-ends of the vRNA segment which is covered by multiple copies of NP. This macromolecular complex replicates the viral genome in the nucleus of infected cells and makes many contacts with cellular partners for its assembly. We have gained evidences that IDV NP uses the importins-α system, similar to influenza A and B nucleoproteins. By using advanced techniques of modern biology and physics (X-ray, electron microscopy, surface plasmon resonance, fluorescence anisotropy, ...), the aims of this project are 1/ to provide structural and functional data on IDV and ToadV nucleoproteins and also on their interactions with host partners, and 2/ to highlight both the common and specific features of all types of influenza NPs, giving precious insights on the evolution processes occurring within this growing family of viruses.

https://www.ibs.fr/IMG/pdf/affiche_these_2021_01_donchet.pdf

Contact : odile.rossignol@cea.fr

Discipline évènement : (Biologie / Chimie)
Entité organisatrice : (CEA / IRIG)
Nature évènement : (Soutenance de thèse)

Prévenir un ami par email

Télécharger dans mon agenda

Cafés sciences de Grenoble | UdPPC de Grenoble | Sauvons Le Climat | Cafe des sciences de Vizille
Accueil du site | Secretariat | Espace privé | Suivre la vie du site RSS 2.0 : Tous les evenements Suivre la vie du site RSS 2.0 : Evenements de Physique Suivre la vie du site RSS 2.0 : Evenements de Biologie & Chimie