Heparan sulfate design : regulation of biosynthesis

Orateur : Lena KJELLEN (University of Uppsala, Sweden, Department of Medical Biochemistry and Microbiology)

All vertebrate cells examined express heparan sulfate proteoglycans at their cell surfaces. The heparan sulfate polysaccharide chains of the proteoglycans bind to secreted signaling proteins, including growth factors, cytokines, and morphogens, to affect their tissue distribution and signaling, thereby controling key processes in development and homeostasis. The sulfation pattern of the heparan sulfate chains will determine if an interaction with a potential ligand will take place, as well as the affinity of the interaction. It is therefore important to understand how the sulfation patterns are formed during biosynthesis and how this process is regulated in different biological contexts.

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