Corticostriatal substrates of incentive habits : new insights into the pathophysiology of addiction

Orateur : David BELIN (Inserm Avenir Team “Psychobiology of Compulsive Disorders” and Inserm European Associated Laboratory of Psychobiology of Compulsive Habits at Inserm Unit 1084, Laboratory of Experimental and Clinical Neurosciences, University of Poitiers)

Drug addiction may be associated with a loss of executive control over maladaptive incentive habits. We hypothesize that these incentive habits result from a pathological coupling of drug-influenced motivational states and a rigid stimulus response habit system by which drug-associated stimuli through automatic processes elicit and maintain drug seeking. Neurally, incentive habits may depend upon an interaction between the basolateral amygdala and nucleus accumbens core, together with the progressive development of a ventral to dorsolateral striatum functional coupling through the recruitment of striato-nigro-striatal dopamine-dependent loop circuitry. Recent evidence suggests that both ventral striatal and central nucleus pathways from the amygdala may be required for the recruitment of DLS-dependent control over habitual behavior.

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