Targeting the peroxides detoxification metabolism of Plasmodium falciparum
Vendredi 12 avril 2013 14:00
- Duree : 1 heure
Lieu : CIBB seminar room, ILL - 6 rue Jules Horowitz - Grenoble
Orateur : Adriana Erica MIELE (University of Rome “La Sapienza”, Italy)
Malaria is one of the major treats for human health worldwide, causing about 1 million deaths per year. It is a vector borne disease, caused by parasites of the genus Plasmodium, among which P. falciparum is the most deadly species and the one with the highest rate of drug resistance. The parasite has a complex developmental cycle, including a continuous expansion inside host erythrocytes. Therefore it is exposed to high fluxes of reactive oxygen species (ROS), while maintaining a reduced intracellular environment. Therefore it evolved a complex network of NADPH dependent redox enzymes : a complete glutathione (GSH) system and a specialized thioredoxin (Trx) system. I shall present some insights resulting from a focused structural genomics approach.
Contact : sultan@ill.fr
Discipline évènement : (Physique)
Entité organisatrice : (ILL)
Nature évènement : (Séminaire)
Evènement répétitif : (General ILL Seminar - College 8)
Site de l'évènement : Polygone scientifique
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